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Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest

Françoise Dellu-Hagedorn, Marion Rivalan, Aurélie Fitoussi, Philippe De Deurwaerdère
Published 26 February 2018.DOI: 10.1098/rstb.2017.0154
Françoise Dellu-Hagedorn
INCIA, UMR 5287, Univ. Bordeaux, F-33000 Bordeaux, FranceINCIA, UMR 5287, CNRS, F-33000 Bordeaux, France
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  • ORCID record for Françoise Dellu-Hagedorn
  • For correspondence: francoise.dellu@u-bordeaux.fr
Marion Rivalan
INCIA, UMR 5287, Univ. Bordeaux, F-33000 Bordeaux, FranceINCIA, UMR 5287, CNRS, F-33000 Bordeaux, France
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Aurélie Fitoussi
INCIA, UMR 5287, Univ. Bordeaux, F-33000 Bordeaux, FranceINCIA, UMR 5287, CNRS, F-33000 Bordeaux, France
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Philippe De Deurwaerdère
INCIA, UMR 5287, Univ. Bordeaux, F-33000 Bordeaux, FranceINCIA, UMR 5287, CNRS, F-33000 Bordeaux, France
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Abstract

Several impulse control disorders such as ADHD, mania, personality disorders or substance abuse share common behavioural traits, like impulsiveness, risk-taking or inflexible behaviour. These disorders are treated with drugs targeting dopamine (DA) and/or serotonin (5-HT). However, the patient's monoamine imbalance that these neurotransmitters compensate is unclear. This study aims to investigate the patterns of DA and 5-HT metabolisms at rest within selected brain regions related to inter-individual variability in six main components of impulsivity/compulsivity (anticipatory hyperactivity, premature responses, delay discounting, risk-taking, perseveration, flexibility). Rats with adaptive and highly inadaptive behaviours were identified in each task and a sensitive biochemical approach allowed mapping of post-mortem endogenous monoamine tissue content in 20 brain areas. Distinct patterns of 5-HT and DA metabolisms were revealed according to the behavioural traits. Except for hyperactive responses, lower control of actions was mainly associated with a lower DA or 5-HT metabolism in prefrontal and/or subcortical areas (i.e. in orbitofrontal cortex (DA), amygdala and anterior cingulate cortex (5-HT) for inflexible and risk-prone rats). Our results reveal the complex nature of behavioural traits related to impulse control disorders through their associated monoaminergic networks at rest, paving the way for understanding the link between mental disorders and drug therapeutic actions.

This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.

Footnotes

  • Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9.figshare.c.3969018.

  • One contribution of 20 to a theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences’.

  • Accepted October 17, 2017.
  • © 2018 The Author(s)
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19 April 2018
Volume 373, issue 1744
Philosophical Transactions of the Royal Society B: Biological Sciences: 373 (1744)
  • Table of Contents
Theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences’ compiled and edited by Irina Trofimova, Trevor W. Robbins, William H. Sulis and Jana Uher

Keywords

monoamine tissue content
serotonin
dopamine
impulsivity
risk-taking
inflexibility
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Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest
Françoise Dellu-Hagedorn, Marion Rivalan, Aurélie Fitoussi, Philippe De Deurwaerdère
Phil. Trans. R. Soc. B 2018 373 20170154; DOI: 10.1098/rstb.2017.0154. Published 26 February 2018
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Research article:

Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest

Françoise Dellu-Hagedorn, Marion Rivalan, Aurélie Fitoussi, Philippe De Deurwaerdère
Phil. Trans. R. Soc. B 2018 373 20170154; DOI: 10.1098/rstb.2017.0154. Published 26 February 2018

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